Acteoside ameliorates cerebral ischemia/reperfusion injury in MCAO rats as a natural plasma Kallikrein inhibitor from Osmanthus fragrans flower.

ABSTRACT: Acteoside is the potential bioactive component of Osmanthus fragrans flowers for treating stroke. However, the pharmacological actions, therapeutic targets and underlying mechanisms of acteoside in cerebral ischemia/reperfusion injury remain poorly understood. In this study, we investigated the therapeutic effect, direct target, and the underlying mechanisms of acteoside on cerebral I/R injury in middle cerebral artery occlusion (MCAO) rats. Our study suggested that treatment with OFFE or acteoside significantly reduced cerebral infarct area in MCAO rats. Coagulation function measurement suggested that acteoside treatment increased activated partial thromboplastin time (APTT) and prothrombin time (PT) in vitro. Further molecular docking and enzyme activity assays indicated that acteoside b

SUBMITTER: Wang HH 

PROVIDER: S-EPMC12222688 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature