Network pharmacology of olive stem extract, UPLC-HR-QTOF-MS profiling and antiviral activities aligned with UN sustainable development goals.

ABSTRACT: Olea europaea tree has long been a cornerstone of traditional medicine. Its different parts have been used as a remedy for viral accompanied diseases as asthma, sore throat, fever, and others. Despite its historical significance, olive stem's chemical diversity and pharmacological potential remain underexplored. This study aims to bridge that gap by identifying the phytochemical compounds in stem ethanolic extract using ultra-performance liquid chromatography coupled to high-resolution quadrupole time of flight mass spectrometer (UPLC-HR-QTOF-MS). Additionally, it assesses the extract's cytotoxic effects using MTT assay and antiviral activities against HSV-1, coxsackievirus-B4, and adenovirus-7. Network pharmacology was employed to understand the potential compound-target pathways. The ana

SUBMITTER: Mohamaden YM 

PROVIDER: S-EPMC12222765 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature