Residential proximity to national priorities list superfund sites is associated with increased likelihood of metastatic breast cancer presentation.

ABSTRACT: Breast cancer (BCa) is the most diagnosed female malignancy globally. While genetic and behavioral causes are known determinants of risk and stage at diagnosis, less is known about how environmental exposures influence etiology and progression. This study evaluates the association between National Priorities List (NPL) superfund site (SF) proximity and metastatic BCa presentation. The Florida Cancer Data System (FCDS) was used to source female BCa cases diagnosed between 2015 and 2019 with valid census tract identification numbers. NPL proximity was defined as ≥ one NPL site within census-designated place (CDP) of residence. Multivariable analyses were performed to assess association between SF proximity and increased odds of metastatic versus non-metastatic BCa presentation. 21,505 BCa ca

SUBMITTER: Borowsky PA 

PROVIDER: S-EPMC12222789 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature