Association between liver fibrosis scores and cardiovascular disease in elderly based on NHANES 1999-2018.

ABSTRACT: This study aimed to assess the association between liver fibrosis scores (LFSs) and cardiovascular disease (CVD) in older adults, investigating the mediating effect of total bilirubin (TBil) between LFSs and CVD. Using data from the National Health and Nutrition Examination Survey (NHANES) between 1999 and 2018, this cross-sectional study analyzed Americans aged 60 and older. Four LFSs (Forns Score, FIB-4, NAFLD fibrosis score, and BARD Score) were utilized. Weighted logistic regression and smoothed curve fitting explored the relationship between LFSs and CVD. Subgroup analysis assessed this relationship among different populations. Mediation effect analysis examined the role of TBil. This study included 18,902 subjects, with a mean age of 69.64 ± 7.00 years and CVD prevalence of 22.33%. T

SUBMITTER: Du M 

PROVIDER: S-EPMC12222800 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature