Integrated analyses to explore the mechanism of Gancao Renshen Zhixue Decoction in treating liver cirrhosis.

ABSTRACT: The study aims to explore the key mechanism of Gancao Renshen Zhixue Decoction (GCRSZXD) in treating liver cirrhosis (LC). Common targets of GCRSZXD and LC were obtained, and the hub genes were identified by network construction and differential expression analysis. Key active ingredients were determined by intersecting the top 10 common target-related and hub gene-related active ingredients. Then, enrichment analysis was performed to identify the essential pathways. Besides, the GCRSZXD-Chinese herb-active ingredient-hub gene-signaling pathway-LC network was constructed to explore potential regulatory mechanisms. Molecular docking and molecular dynamic simulation were used to verify the binding ability of key active ingredients with hub genes. Finally, hub gene expression was validated in

SUBMITTER: Pan J 

PROVIDER: S-EPMC12222815 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature