Midodrine and clinical outcomes in patients on maintenance hemodialysis.

ABSTRACT: Patients on hemodialysis often experience intradialytic hypotension (IDH), contributing to increased cardiovascular disease and mortality. Midodrine, an α-1 adrenergic receptor agonist, is commonly prescribed for IDH treatment or prevention. However, the effects of midodrine on clinical outcomes remain unclear. We aimed to evaluate the impact of midodrine use on clinical outcomes in patients on maintenance hemodialysis. This retrospective study evaluated patients according to midodrine prescriptions based on a dataset from the hemodialysis quality assessment program and Health Insurance Review and Assessment. Propensity score matching was employed to minimize bias in baseline characteristics. The Cox regression model was used to estimate the hazard ratio (HR) and confidence interval (CI) f

SUBMITTER: Jeon J 

PROVIDER: S-EPMC12222820 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature