Effects of paternal age and interaction with smoking, alcohol consumption and maternal age on implantation failure in women undergoing ART.

ABSTRACT: It remains unclear whether there is an independent association of paternal age with implantation failure (IF) in couples undergoing Assisted Reproductive Technology (ART) treatment. Little is known about the interactive effects of paternal age with maternal age, paternal smoking and alcohol consumption on IF. The Anhui Maternal-Child Health Cohort Study (AMCHS) interviewed 1910 infertile couples (paternal age ranged 22-57 years) to look for risk factors associated with IF. Implantation outcome was assessed using serum β-HCG between 0 and 25 IU/L 14 days post-embryo transfer. Odds ratios (ORs) for IF in relation to paternal age, and its interactions with maternal age, paternal smoking and alcohol consumption were evaluated using logistic regression models. The risk of IF (n = 735) increased

SUBMITTER: Yin J 

PROVIDER: S-EPMC12222860 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature