The mechanism of Shancigu and its monomer in the development of colorectal cancer based on network pharmacology.

ABSTRACT: Shancigu has traditionally been used for clearing heat, detoxification, resolving phlegm, and dissipating masses. However, its potential mechanisms in colorectal cancer (CRC) remain unclear. This study aimed to explore the molecular mechanisms of Shancigu and its active compound in CRC. The active ingredients of Shancigu and their predicted targets were identified, and differentially expressed genes (DEGs) associated with CRC metastasis and invasion were screened. Intersection genes were obtained and used to construct a protein-protein interaction (PPI) network. Core genes were identified, and their prognostic significance was analyzed. Molecular docking was performed between key survival-related genes and Shancigu compounds. Further in vitro, organoid, and in vivo experiments were conduct

SUBMITTER: Li G 

PROVIDER: S-EPMC12222874 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature