Genomic analysis for the identification of bioactive compounds in Xenorhabdus stockiae strain RT25.5.

ABSTRACT: Elucidating microorganism genomes holds great promise for the discovery of novel bioactive compounds with diverse applications. In this study, we investigated the complete genome of Xenorhabdus stockiae strain RT25.5, which is recognized for its symbiotic association with entomopathogenic nematodes (EPNs) and its biosynthesis of secondary metabolites relevant to the pharmaceutical industry, agriculture, and ecology. Through high-throughput genome sequencing, assembly, and annotation, followed by advanced bioinformatics analyses, we elucidated the genetic basis of its antimicrobial potential. Our analysis revealed 21 putative biosynthetic gene clusters (BGCs) associated with bioactive compound production. Notably, LC‒MS/MS analysis of the bacterial cultures confirmed the presence of diverse

SUBMITTER: Meesil W 

PROVIDER: S-EPMC12222877 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature