Donor and recipient genetic variants in drug metabolizing enzymes and transporters affect early tacrolimus pharmacokinetics after liver transplantation.

ABSTRACT: This study examines the influence of single nucleotide polymorphisms in drug metabolizing enzymes CYP3A4, CYP3A5, and UGT1A4, and the transporter ABCB1 on tacrolimus dose requirements and blood trough level variability in the period immediately after liver transplantation. We analyzed genotypes for these genes in 61 adult liver transplant recipients who received tacrolimus and their respective donors. Significant findings include increased average daily deviation (ADD) from the therapeutic range in patients with: donor CYP3A4*22 GG (1.68 [1.01, 2.29] versus 0.68 [0.42, 1.46] ng/mL/day, p = 0.016), recipient ABCB1 rs2032582 CT/TT (2.07 [1.68, 2.39] versus 1.37 [0.76, 1.95] ng/mL/day , p = 0.013), and donor UGT1A4*3 TT (1.69 [1.02, 2.42] versus 1.33 [0.54, 1.79] ng/mL/day , p = 0.043). Addit

SUBMITTER: Ladd AD 

PROVIDER: S-EPMC12223032 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature