Selected strains of the Ganoderma lucidum complex from Finnish forests have excellent broadly acting antiviral properties.

ABSTRACT: Broadly acting antivirals are needed to complement vaccines in present and future pandemics and outbreaks as safe and sustainable tools for combating virus infections. Thus, the current study aims to investigate the broad-spectrum antiviral activity of ferments of selected strains belonging to the Ganoderma lucidum complex isolated from Finland and investigate their mechanism of action. Cytopathic effect inhibition assay and endpoint assay were used to determine the antiviral activity. The antibacterial activity ws examined using recombinant biosensor strains. Mechanism of action studies included time of addition assay, transmission electron microscopy, confocal microscopy, sucrose gradient separation assay, and thermal assay. The metabolite composition of the ferments was studied using UH

SUBMITTER: Reshamwala D 

PROVIDER: S-EPMC12223054 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature