Preoperative renal functional reserve as a predictor of acute kidney injury in young adults with congenital heart disease.

ABSTRACT: Due to advances in medical and surgical care, there are more adults than children living with congenital heart disease (CHD). Acute kidney injury (AKI) is a common complication following cardiac surgery in patients with CHD, with creatinine lacking sensitivity for early detection. Renal functional reserve (RFR), the kidney's capacity to increase filtration under stress, has emerged as a potential predictor of AKI. Our primary study objective was to evaluate whether preoperative RFR, using both creatinine clearance (CrCl) and cystatin C estimated glomerular filtration rate (eGFR) methods, predicts AKI following cardiopulmonary bypass in young adults with CHD. As a secondary objective, we compared RFR in CHD patients to that of healthy controls. This prospective cohort study included 30 youn

SUBMITTER: Fuhrman DY 

PROVIDER: S-EPMC12223075 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature