Meta-analysis and in-silico functional characterization of the SNCA variant rs356220 in Parkinson's disease.

ABSTRACT: The progression of Parkinson's disease (PD) is influenced by genetic factors, particularly the Synuclein-Alpha (SNCA) gene, which encodes the alpha-synuclein (α-syn) protein involved in dopaminergic neuron degeneration. This study aimed to explore the relationship between rs356220 and PD risk and to understand its functional impact through computational analysis. We thoroughly reviewed nine databases regarding the association between this variant and PD risk. Firstly, a meta-analysis of 9 articles, consisting of 10 studies with 11,638 cases and 37,393 controls was conducted, that identified the C allele of rs356220 as a protective factor against PD (Odds Ratio (OR) 0.91, 95% Confidence Interval (CI): 0.88-0.94, P = 3.82E-08)). Subsequently, we characterized the functional impact of this no

SUBMITTER: Menon S 

PROVIDER: S-EPMC12223105 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature