A lentiviral vector targeting a KRAS neoepitope for cancer immunotherapy.

ABSTRACT: Mutated oncogenic Kirsten rat sarcoma virus (KRAS) antigen is expressed in a large variety of cancers, including pancreatic, colorectal, and pulmonary cancers. The oncogenic KRAS mutations cause malignancies and are usually ubiquitously expressed by all cells of a tumor. The KRAS amino acid substitutions at the positions 12 or 13 are among the most frequent mutations in human cancers. Here, we developed immuno-oncotherapeutic non-integrative lentiviral vectors encoding a segment encompassing KRAS^G12D, either alone, or associated with antigen carriers. These carriers can improve the intracellular antigen routing to major histocompatibility complex presentation machineries or provide universal helper CD4⁺ epitopes. Immunotherapy with one of these vectors resulted in sig

SUBMITTER: Goloudina A 

PROVIDER: S-EPMC12223123 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature