Lactococcus cremoris YRC3780 improves subjective stress response in the Uchida-Kraepelin test: a randomized, double-blind, placebo-controlled study.

ABSTRACT: Lactococcus cremoris YRC3780, isolated from kefir, likely improves the hypothalamic-pituitary-adrenal axis response to acute psychological stress by acting on intestinal immune cells and promoting cytokine production. Here we examined the effectiveness of YRC3780 on the stress response in healthy Japanese adults. We investigated the effects of daily YRC3780 intake on the stress response in a randomized, placebo-controlled, double-blind, parallel-group study of 107 healthy Japanese adults (54 in the YRC3780 group and 53 in the placebo group) who had an initial positive Uchida-Kraepelin (U-K) test stress response. After 8 weeks, the POMS2 Total Mood Disturbance (TMD) score after the U-K test and the change in score from baseline score were significantly better in the YRC3780 group than in th

SUBMITTER: Fujioka I 

PROVIDER: S-EPMC12223139 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature