Characterization of Neurensin-2 knockout mice: insights into stress-resilience mechanisms.

ABSTRACT: Major depressive disorder (MDD) affects millions worldwide, yet its pathophysiology remains poorly understood. While some individuals are susceptible to developing depression, others show resilience that protects them from developing MDD. Understanding the resilience-associated mechanisms will likely result in novel therapies for MDD. We have recently reported that the vesicular protein Neurensin-2 mediates depression and that its deletion confers profound resilience to chronic stress. Nonetheless, the behavioral and molecular adaptations that underlie the stress resilience in Neurensin-2 knockout mice are still unknown. In this study, we aimed to comprehensively characterize the basal behavioral effects of Neurensin-2 deletion in mice. We used Neurensin-2 knockout male and female mice to

SUBMITTER: Hovav HC 

PROVIDER: S-EPMC12223177 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature