Roles of MARCKSL1, MCM6, RFC4, and PLAU genes in esophageal cancer and their association with radiotherapy response.

ABSTRACT: Esophageal cancer is a highly lethal malignancy with high incidence and mortality rates, which continue to pose a significant threat to public health worldwide. Despite the adoption of multidisciplinary treatments, improving long-term survival rates remains a major challenge. Therefore, conducting in-depth research into the molecular mechanisms of esophageal cancer, identifying predictive biomarkers, and developing personalized treatment and monitoring strategies are crucial to enhancing clinical outcomes and patient prognosis. This study utilized advanced bioinformatics techniques to construct a gene co-expression network for esophageal cancer and compared it with sequencing data from real-world esophageal cancer samples. This approach successfully identified four key genes closely associ

SUBMITTER: Zeng B 

PROVIDER: S-EPMC12223209 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature