Etiological mechanisms underlying the hazard factors and inflammatory bowel disease: a prospective cohort study.

ABSTRACT: Inflammatory bowel disease (IBD) is a progressively advancing immune-mediated disorder characterized by intricate pathophysiological features. Despite extensive research, the mechanisms linking various risk factors to the development of IBD remain incompletely understood. We conducted analyses within a prospective cohort of unrelated European individuals, utilizing data from the UK Biobank. This cohort had over a decade of follow-up and included more than 500,000 participants aged between 37 and 73 years at recruitment, which took place between 2006 and 2010. A multivariate Cox proportional model was employed to investigate the impact of different risk factors on the incidence of IBD. Additionally, we examined the relationship between 220 peripheral biomarkers and the occurrence of IBD. Fi

SUBMITTER: Tao Y 

PROVIDER: S-EPMC12223230 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature