Two unreported lecanoric acid derivatives isolated from Chaetomium globosum KM651986 and their anti-diabetic effect.

ABSTRACT: The genus Chaetomium, Chaetomiaceae, is a promising source of secondary metabolites with proven pharmacological activities. In the present study, a new strain of Chaetomium globosum (KM651986) was investigated resulting in the isolation of two unreported lecanoric acid derivatives 1 and 2, for the first time, which were analyzed using spectroscopic methods, SwissSimilarity, and SwissTargetPrediction. Thus, predicting the possible biological targets for 1 and 2. Consequently, the crude methanol extract of C. globosum, compounds 1 and 2 were investigated for their anti-diabetic activity using streptozocin (STZ) - induced diabetic rat model. Results indicated that the crude extract C. globosum and compounds 1 and 2 significantly impacted serum glucose, insulin, HbA1c levels, hepatic glucose-6

SUBMITTER: Hussein RA 

PROVIDER: S-EPMC12223274 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature