Oxidative stress markers and inflammation in type 1 and 2 diabetes are affected by BMI, treatment type, and complications.

ABSTRACT: Diabetes mellitus (DM) is a common global metabolic disease. Oxidative stress from reactive oxygen species (ROS) contributes to its development and leads to complications like heart disease, kidney failure, and stroke. Chronic inflammation in diabetes is associated with insulin resistance and elevated glucose levels, as indicated by increased markers of interleukin-6 (IL-6), C-reactive protein (CRP), and tumor necrosis factor-alpha (TNF-α). This study investigates the activity and concentration of antioxidant enzymes (SOD, GPX1, CAT) and inflammatory markers (IL-6, CRP, TNF-α) in patients with type 1 and type 2 diabetes compared to healthy controls. The study included 73 patients-33 with type 1 diabetes (18 men, 15 women) and 40 with type 2 diabetes (20 men, 20 women)-and 41 healthy contro

SUBMITTER: Cecerska-Heryc E 

PROVIDER: S-EPMC12223297 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature