Dinuclear Copper Complex with a Pyridazine-Bridged Octadentate Ligand: Monooxygenase Activity and Characterization of Copper-Oxygen Intermediates.

ABSTRACT: Copper-containing enzymes catalyze the mono-oxygenation of aromatic and aliphatic substrates in nature. Herein, we report on the synthesis of a new dinuclear copper complex supported by an octadentate ligand with a pyridazine backbone. Low-temperature oxygenation leads to a μ-1,1-hydroperoxo dicopper(II) (Cu₂OOH) complex, which in turn stoichiometrically converts anthrone (AT) to anthraquinone (AQ). Oxygenation at room temperature, by contrast, leads to a new species that mediates the conversion of AT to AQ in a catalytic fashion, but neither corresponds to a μ-peroxo nor a mono μ-oxo dicopper complex. For further analysis, a μ-hydroxo dicopper(II) (Cu₂OH) complex is synthesized by oxidation of the copper(I) complex with AgOTf. The electronic and geometric structures

SUBMITTER: Stuber A 

PROVIDER: S-EPMC12223343 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature