Misaligned feeding uncouples daily rhythms within brown adipose tissue and between peripheral clocks.

ABSTRACT: Extended food consumption during the rest period perturbs the phase relationship between circadian clocks in the periphery and the brain, leading to adverse health effects. Beyond the liver, how metabolic organs respond to a timed hypocaloric diet is largely unexplored. We investigated how feeding schedules impacted circadian gene expression in epididymal white and brown adipose tissue (eWAT and BAT) compared to the liver and hypothalamus. We restricted food to either daytime or nighttime in C57BL/6J male mice, with or without caloric restriction. Unlike the liver and eWAT, rhythmic clock genes in the BAT remained insensitive to feeding time, similar to the hypothalamus. We uncovered an internal split within the BAT in response to conflicting environmental cues, displaying inverted oscilla

SUBMITTER: Acosta-Rodriguez VA 

PROVIDER: S-EPMC12223410 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature