Genetic Ancestry, Intrinsic Tumor Subtypes, and Breast Cancer Survival in Latin American Women.

ABSTRACT: This study investigates the relationship between genetic ancestry, breast cancer subtypes, and survival outcomes among 951 locally advanced breast cancer cases from Argentina, Brazil, Chile, Mexico, and Uruguay, participating in the Molecular Profile of Breast Cancer Study. Array-based genotyping and ADMIXTURE analysis were used for genetic ancestry evaluation. Breast cancer subtypes were defined by IHC and the gene expression-based PAM50 algorithm. The distribution of genetic ancestry, including European, Indigenous American (IA), African (AFR), and East Asian components, revealed a heterogeneous genetic admixture across countries, with the highest IA ancestry observed in Chile (30.9%) and Mexico (30.8%). Testing the relationship between genetic ancestry and breast cancer subtypes demonst

SUBMITTER: Alves da Quinta D 

PROVIDER: S-EPMC12223717 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature