2D and 3D Models of Alzheimer's Disease: Investigating Neuron-like Cells in Oxidative Environments.

ABSTRACT: Alzheimer's disease (AD) is a complex and enigmatic neurodegenerative disorder in which amyloid-β (Aβ) aggregates and oxidative stress play crucial roles in neuronal damage. Aβ forms senile plaques, while reactive oxygen species (ROS)-induced oxidative stress causes cellular dysfunction. Elucidating neuronal injury led by mild and severe oxidative stress may provide insight into how neurons respond to toxic environments. In parallel, modeling AD three-dimensionally is in the spotlight, sustainably contributing to reducing animals in research and replicating spatially neuronal mechanisms, such as neurite network and oxidative stress responses. This study evaluates the effects of oxidative stress on neuron-like cells cultured in two-dimensional (2D) and 3D spheroids, strengthening their pote

SUBMITTER: Salles GR 

PROVIDER: S-EPMC12223811 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature