Adjuvant Effect of Mesoporous Silica SBA-15 of Different Morphologies on Antidiphtheria Immune Response.

ABSTRACT: Ordered mesoporous silica SBA-15 improves the humoral response as a vaccine adjuvant because of its structural properties. Its morphology is dependent on synthesis conditions and can alter antigen encapsulation and immune response; all tested variants were safe and able to immunize against diphtheria. One of the additional advantages of SBA-15 is that its morphology can be modulated by adjusting the synthesis conditions like temperature, stirring speed, and solvent addition. In this study, SBA-15 was selected as a vaccine adjuvant in immunization against diphtheria by varying four modifications of the synthesis parameters for preparing SBA-15 particles with different morphologies. SEM analyses confirmed that different morphologies were obtained including rope-shaped aggregated rods (S1), f

SUBMITTER: Miranda MCR 

PROVIDER: S-EPMC12223812 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature