Ultrasmall Copper-Based Nanozyme Eye Drops for Effective Antioxidative Therapy of Ocular Surface Diseases.

ABSTRACT: Developing an effective strategy to mitigate the excessive production of reactive oxygen species (ROS) caused by diverse factors is crucial for preventing ocular surface diseases. However, due to the inherent characteristics of ocular barriers, the therapeutic efficacy of conventional eye drops remains unsatisfactory. Copper-based nanozymes are known for their enzyme-mimetic ROS scavenging abilities. In this study, we report a simple, ecofriendly, one-step synthesis of ultrasmall copper Cu_5.4O nanoparticles (NPs) as antioxidant and anti-inflammatory nanozymes in eye drop formulations. The Cu_5.4O NPs showed strong hydrogen peroxide (H₂O₂) scavenging ability and reduced intracellular ROS in corneal cells in vitro. In vitro hemolysis s

SUBMITTER: Qiao R 

PROVIDER: S-EPMC12223838 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature