The Nobilamides: Potent Biofilm Inhibitors Produced by the Microbiota of Moon Snail Egg Masses.

ABSTRACT: Bacterial biofilm infections have become increasingly challenging to treat as bacteria living in a biofilm state are more resistant to antibiotics and protected from the host immune response. Eradicating biofilm infections generally requires treatment with high doses of antibiotics for prolonged periods; however, the rise in antibiotic resistance further challenges these treatments. Unfortunately, there are no approved drugs that inhibit or disrupt biofilm formation. Here, we leveraged our library of bacteria associated with moon snail egg masses found in Puerto Rico, using mass spectrometry-based metabolomics, to discover biofilm inhibitors. Analysis of a chemical fraction library revealed a set of peptides in fractions exhibiting potent inhibition of biofilms. Bioassay-guided isolation l

SUBMITTER: Kyei L 

PROVIDER: S-EPMC12223873 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature