Comparative safety of B/F/TAF versus other antiretroviral therapy regimens for treatment-naive people with HIV-1: a systematic literature review and network meta-analysis.

ABSTRACT: Aim: Bictegravir, emtricitabine and tenofovir alafenamide (B/F/TAF) is a single-tablet regimen approved for the treatment of HIV-1 in treatment-naive (TN) and virologically suppressed people with HIV-1 (PWH). While the efficacy of antiretroviral therapy (ART) regimens in TN PWH is well established, regimen selection is often influenced by safety and tolerability concerns. This systematic literature review and network meta-analysis compares the safety outcomes of B/F/TAF with other ART regimens in TN PWH, addressing a key aspect of therapeutic decision-making. Materials & methods: A systematic literature review was performed to identify phase III and IV RCTs assessing B/F/TAF and comparator regimens in TN adults (≥18 years) with HIV-1. MEDLINE, Embase, Cochrane Database of Sys

SUBMITTER: Curteis T 

PROVIDER: S-EPMC12224115 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature