Paired Deep Brain Stimuli Elicit Short-Term Facilitation in Globus Pallidus Interna and Subthalamic Nucleus.

ABSTRACT:

Background

Deep brain stimulation (DBS) elicits oscillatory local field potentials in patients with Parkinson's disease (PD) and other movement disorders. Greater knowledge about the fast dynamics of these neural responses could shed light on circuit pathophysiology and inform novel approaches to neuromodulation therapies.

Objectives

To compare short-term neuroplasticity in the globus pallidus interna (GPi) and the subthalamic nucleus (STN), the canonical functional targets for PD and dystonia.

Methods

During surgery for DBS lead implantation, we delivered pairs of stimuli across various interstimulus intervals and amplitudes and recorded DBS-evoked responses from unused contacts on the lead. After stimulus artifact removal, we contrasted the magnitude and timing of t

SUBMITTER: Brinkerhoff S 

PROVIDER: S-EPMC12224288 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature