Regulatory Genes as Beacons for Discovery and Prioritization of Biosynthetic Gene Clusters in <i>Streptomyces</i>.

ABSTRACT: Actinobacteria are renowned for their ability to produce a wide range of bioactive molecules, including many anticancer compounds and antibiotics that are critical in the battle against antimicrobial resistance. Despite identification of a vast array of biosynthetic gene clusters (BGCs) through genome mining, much of this biosynthetic potential remains unexplored, partially due to the fact that many remain silent or cryptic under typical laboratory conditions. Regulatory networks can provide clues to the location of yet undiscovered gene cluster families or be leveraged to predict their expression. Here, we investigate the associations between regulatory genes and BGCs to uncover their predictive capabilities in discovering and prioritizing gene clusters for downstream wet-lab validation.

SUBMITTER: Augustijn HE 

PROVIDER: S-EPMC12224297 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature