Synthesis of novel trans-2,3-dihydrofuran-pyrazole conjugates through molecular hybridization: molecular docking insights and evaluation of anti-inflammatory and anti-malarial activities.

ABSTRACT: A series of some new trans 2,3-dihydrofuran-linked pyrazole hybrids were synthesized from a convenient one-pot methodology. This procedure employs a sequential one-pot, two-step tandem reaction starting from pyridine, formylpyrazole, dimedone, and phenacyl bromide, with triethylamine serving as the base and proceeds efficiently in acetonitrile. The recently synthesized compounds were characterized through ¹H and ¹³C NMR, Mass and IR spectroscopy and evaluated for their anti-inflammatory and anti-malarial potentials. Among the evaluated compounds, the derivative 4l, featuring a bromo group on the acetylphenyl and a methoxy group on the formylpyrazole phenyl ring, demonstrated potent anti-inflammatory activity with an IC₅₀ value of 7.12 ± 0.03 μM. This potenc

SUBMITTER: Kumari G 

PROVIDER: S-EPMC12224374 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature