Evaluation of kidney injury and metabolomic analysis in adulthood in a non-obese hyperglycemic female mouse model after birth with low birthweight.

ABSTRACT: Low birthweight infants have high risk of developing chronic kidney disease (CKD) in later in life, however, the pathogenesis of this disease remains unclear. This study aimed to investigate the underlying mechanism using a low birthweight-non-obese hyperglycemic adulthood mouse model. Pregnant ICR-strain mice underwent uterine artery ligation at day 16.5 of gestation to induce fetal hypoxia (ischemic group, I). Female newborns were weaned at 4 weeks of age and fed a normal diet until 8 weeks of age (n = 10). The group I was compared to the control group (C) regarding the body weight, tubular injury markers, renal function, pathology, and metabolome analysis. Group I were born with a low birth weight (group I: C = 1.4:1.9 g, p < 0.01), which persisted after birth. By 8 weeks of age, there

SUBMITTER: Shimizu S 

PROVIDER: S-EPMC12224424 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature