MYO1B promotes radioresistance in head and neck squamous cell carcinoma by regulating tumor stemness and DNA damage repair via the PI3K/AKT pathway.

ABSTRACT: Head and Neck Squamous Cell Carcinoma is a prevalent malignancy characterized by high recurrence rates. While surgery remains the primary treatment, postoperative radiotherapy is essential for preventing tumor recurrence. However, the mechanisms driving radiotherapy resistance in HNSC remain largely unknown. With a multi-layered approach encompassing bioinformatics analysis, clinical tissue sample validation, in vitro and in vivo experiments, we discovered that MYO1B played a critical role in radiotherapy resistance of HNSC. Our findings underscored that MYO1B was significantly overexpressed in HNSC tissues and was associated with poor prognosis, particularly in patients undergoing radiotherapy. Functional investigations revealed that knockdown of MYO1B reduced the expression of stemness m

SUBMITTER: Li Y 

PROVIDER: S-EPMC12224464 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature