X-ray velocimetry provides temporally and spatially-resolved biomarkers of lung ventilation in small airways disease.

ABSTRACT:

Background

Small airways disease is a feature of many respiratory conditions. Currently available methods of diagnosing small airways lack sensitivity and/or cannot evaluate spatial heterogeneity. New diagnostic strategies for diagnosing small airways disease are needed.

Methods

We determined the regional displacement of lung tissue calculated from fluoroscopic lung images acquired at multiple angles over sequential time points as a surrogate of ventilation. We applied this technique, which we call X-ray velocimetry (XV), to patients with chronic obstructive pulmonary disease (COPD) and impaired spirometry and veterans with deployment-related constrictive bronchiolitis (DR-CB) but preserved spirometry to determine XV-derived biomarkers specific for each condition.

Results

SUBMITTER: Richmond BW 

PROVIDER: S-EPMC12224510 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature