High-throughput genetic mapping discovers novel zinc toxicity response loci in <i>Drosophila melanogaster</i>.

ABSTRACT: Heavy metals are a widespread environmental contaminant, and even low levels of some metals can disrupt cellular processes and result in DNA damage. However, the consequences of metal exposure are variable among individuals, with susceptibility to metal toxicity representing a complex trait influenced by genetic and non-genetic factors. To uncover toxicity response genes, and better understand responses to metal toxicity, we sought to dissect resistance to zinc, a metal required for normal cellular function, which can be toxic at high doses. To facilitate efficient, powerful discovery of Quantitative Trait Loci (QTL) we employed extreme, or X-QTL mapping, leveraging a multiparental, recombinant Drosophila melanogaster population. Our approach involved bulk selection of zinc-resistan

SUBMITTER: Hanson KM 

PROVIDER: S-EPMC12224547 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature