Investigating the potential role of EIF2S2 in OSCC progression through comprehensive bioinformatics analysis and experimental validation.

ABSTRACT:

Background

The expression of EIF2S2 in oral squamous cell carcinoma (OSCC) may be closely linked to tumor progression and immune evasion.

Objective

To explore the expression patterns of EIF2S2 in OSCC and its associations with the immune microenvironment, mutational burden, drug sensitivity, and prognosis.

Methods

We studied the functionality of EIF2S2 through tissue sample analysis, differential expression analysis, single-cell RNA-sequencing (scRNA-seq), immune scoring, drug sensitivity assessments, and interaction network construction.

Results

EIF2S2 expression was significantly upregulated in OSCC tissues (AUC = 0.846). There were notable differences in immune scoring, cell infiltration, and functional activity between high and low expression groups. The hi

SUBMITTER: Shao Z 

PROVIDER: S-EPMC12224840 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature