Association between the uric acid-to-high-density cholesterol ratio (UHR) and obstructive sleep apnea: mediation by C-reactive protein.

ABSTRACT: Emerging evidence highlights interactions between obstructive sleep apnea (OSA), lipid metabolism, and inflammation, yet the associations bridging inflammatory processes to metabolic dysregulation in OSA remain poorly defined. This study evaluates the uric acid-to-high-density lipoprotein cholesterol ratio (UHR)-a novel composite metabolic-lipid biomarker-and C-reactive protein (CRP), a classical inflammatory marker, to elucidate their associations with OSA and potential mediating pathways. Using data from the National Health and Nutrition Examination Survey (NHANES), we performed weighted multivariable logistic regression to examine associations of UHR and CRP with OSA. Nonlinear relationships were assessed via restricted cubic splines (RCS), and mediation analysis quantified CRP's role i

SUBMITTER: Liu Y 

PROVIDER: S-EPMC12225098 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature