Robust Controlled Degradation of Enzyme Loaded PCL-Based Fibrous Scaffolds Toward Scarless Skin Tissue Regeneration.

ABSTRACT: Uncontrolled degradation of wound dressings may result in residues, causing several negative effects on wound healing, such as secondary damage, undesirable inflammation, and scar skin formation. Here, an available strategy associated with the synthesis of enzyme-loaded (Burkholderia cepacia lipase, BCL) polycaprolactone (PCL) nanofiber scaffolds, aligning with wound healing effects is reported. These scaffolds are fabricated via fiber microfluidic electrospinning degradation-control technique. The obtained scaffolds exhibit tunable degradation rates, achieving complete degradation within 12-72-h cycles. The acidic degradation products are further elucidated and reveal the potential degradation mechanism. The acidic degradation products create an optimal microenvironment during the hemosta

SUBMITTER: Fan L 

PROVIDER: S-EPMC12225112 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature