Comparative assessment of biocompatibility of various fluoride agents in cell culture.

ABSTRACT: This study aimed to evaluate the biocompatibility of various fluoride agents using L929 fibroblast and human gingival fibroblast (HGF) cell cultures. Five different fluoride agents were included in the study; 1.23% Acidulated Phosphate Fluoride (APF) gel (Sultan Health Care, Engle Wood, USA), 2% Sodium Fluoride (NaF) gel (Sultan Health Care, Engle Wood, USA), 1% Titanium Tetrafluoride (TiF₄) solution (Sigma-Aldrich® Chemie GmbH, Steinheim, Germany), 38% Silver Diamine Fluoride (SDF) solution (Saforide®-J. Morita; Toyo Seiyaku Kasei Ltd/Osaka-Japan), and 5% NaF varnish (Duraphat®, Colgate Oral Pharmaceuticals, New York, NY, USA). Cytotoxicity was evaluated using the real-time xCELLigence system, while apoptotic activity was determined through Annexin V/PI and TUNEL assays. Genotoxicity was

SUBMITTER: Aydınel B 

PROVIDER: S-EPMC12225145 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature