DSG3 promotes bladder cancer growth and metastasis via AKT/GSK3β/β-catenin pathway.

ABSTRACT: The high metastasis rate is the primary contributor to the high mortality rate associated with muscle-invasive bladder cancer (MIBC). Therefore, elucidating the mechanisms involved and identifying potential therapeutic targets are crucial for improving the overall prognosis of bladder cancer (BLCA). We used consensus clustering and differential gene expression analyses to identify the key gene desmoglein 3 (DSG3). Subsequently, we examined the expression of DSG3 in BLCA and its association with the clinical characteristics and prognosis. Comprehensive in vitro and in vivo experiments were conducted to elucidate the functions of DSG3 and the reasons behind the upregulation of DSG3 in BLCA, as well as to investigate the mechanisms by which DSG3 promotes metastasis. DSG3 was markedly upregula

SUBMITTER: Wang T 

PROVIDER: S-EPMC12225158 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature