Noninvasive prediction of fetal growth restriction using maternal plasma cell-free RNA: a case-control study.

ABSTRACT:

Background

Fetal growth restriction (FGR) is a significant concern due to its potential adverse outcomes for both mothers and infants. Cell-free RNA in maternal plasma has been suggested as a potential biomarker for pregnancy complications, but its effectiveness in predicting FGR remains uncertain. This study aimed to assess the predictive value of cell-free RNA profiling from maternal plasma collected during early to mid-pregnancy for FGR.

Methods

This case-control study included pregnant women diagnosed with FGR who had non-invasive prenatal test data. Differentially expressed genes (DEGs) between FGR and controls groups were identified through the analysis of cell-free RNA and placental microarray dataset which downloaded from the Gene Expression Omnibus database. The int

SUBMITTER: Huang Y 

PROVIDER: S-EPMC12225434 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature