Antiproliferative activities of phytochemicals isolated from the leaves of Dolichos kilimandischaricus (Harms) ex Taub. (Fabaceae) on Jurkat and HL-60 leukemic cells.

ABSTRACT:

Background

Natural plant products represent one of the most productive sources of innovative lead drugs for the treatment of a wide range of ailments. Dolichos kilimandischaricus (Harms) ex Taub. (Fabaceae) root extracts have been traditionally used for the treatment of HPV-related cancers. The extracts from the plant have been previously shown to have antiproliferative effects on cancer cell lines. This study aimed to isolate, purify, and analyze the phytochemicals from the leaves of D. kilimandischaricus.

Methods

Phytochemicals in the ethanol leaf extract were separated by column chromatography on silica gel. The structures of the compounds were elucidated using spectroscopic techniques, then compared with the reported spectral data. Cytotoxicity of the phytochemicals on H

SUBMITTER: Sithole S 

PROVIDER: S-EPMC12225472 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature