Increased translation in adult mouse striatum is sufficient to induce motor dysfunction.

ABSTRACT: Protein synthesis is a process finely regulated in all cell types but specially in neurons as they need rapid changes in protein concentration for synaptic plasticity. Alterations in translation rates have been shown in diseases affecting the brain. In Huntington's disease (HD), an autosomal dominant neurodegenerative disorder characterized by the presence of motor, cognitive and psychiatric symptoms, we have shown that translation is increased in the striatum contributing to motor symptoms. However, very little is known about how translation modulates motor function in physiological conditions. To study this, we overexpressed a constitutively active mutant form of 4E-BP1 (4E-BP1^F113A), a translation repressor, in the striatum of wild-type mice and performed motor tests. One mon

SUBMITTER: Castany-Pladevall C 

PROVIDER: S-EPMC12225667 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature