Cochlear Cell Atlas of Two Laryngeal Echolocating Bats-New Evidence for the Adaptive Nervous Physiology in Constant Frequency Bat.

ABSTRACT: Bats have evolved highly adapted auditory mechanisms associated with ecological specialisation. However, there is scattered knowledge about the neurophysiological and cellular basis underlying high-frequency hearing in echolocating bats. Herein, the total cochlear cell atlas of Rhinolophus ferrumequinum (constant frequency (CF) bat) and Myotis pilosus (frequency modulated (FM) bat) was conducted using the 10x Genomics single-nucleus RNA sequencing method. Differences in the proportion of cochlear cell types, especially for the neural cells, were detected between these two bat species. Previously, genes upregulated in the cochlea of CF compared with FM bats, were found to be mostly related to nervous activities. After mapping to the cochlear cell atlas, we found that the upregulated genes w

SUBMITTER: Wang X 

PROVIDER: S-EPMC12225709 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature