Dual nature of type I interferon responses and feedback regulations by SOCS1 dictate malaria mortality.

ABSTRACT:

Introduction

Type I interferon (IFN-I, IFN-α/β), precisely controlled by multiple regulators, including suppressor of cytokine signaling 1 (SOCS1), is critical for host defense against pathogens. However, the impact of IFN-α/β on malaria parasite infections, beneficial or detrimental, remains controversial.

Objectives

The contradictory results are suspected to arise from differences in parasite species and host genetic backgrounds. To date, no prior study has employed a comparative approach utilizing two parasite models to investigate the underlying mechanisms of IFN-I response. Moreover, whether and how SOCS1 involves in the distinct IFN-α/β dynamics is still unclear.

Methods

Here we perform single-cell RNA sequencing analyses (scRNA-seq) to dissect the dynamics of I

SUBMITTER: Lu J 

PROVIDER: S-EPMC12225910 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature