CDK4/6 inhibitor PD-0332991 suppresses hepatocarcinogenesis by inducing senescence of hepatic tumor-initiating cells.

ABSTRACT:

Introduction

Owing to the limited treatment options for hepatocellular carcinoma (HCC), interventions targeting pre-HCC stages have attracted increasing attention. In the pre-HCC stage, hepatic tumor-initiating cells (hTICs) proliferate abnormally and contribute to hepatocarcinogenesis. Numerous studies have investigated targeted senescence induction as an HCC intervention. However, it remains to be clarified whether senescence induction of hTICs could serve as a pre-HCC intervention.

Objectives

This study was designed to investigate whether senescence induction of hTICs in the precancerous stage inhibit HCC initiation.

Methods and results

HCC models developed from chronic liver injury (CLI) were established by using Fah^-/- mice and N-Ras + AKT mice. PD-033

SUBMITTER: Chen M 

PROVIDER: S-EPMC12225934 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature