Dialog between mantle cell lymphoma cells and lymphoma-associated macrophages underlies ibrutinib resistance.

ABSTRACT:

Introduction

Patients with mantle cell lymphoma (MCL) frequently develop resistance to ibrutinib. Lymphoma-associated macrophages (LAMs) may play a causal role in this resistance but remain underexplored in current literature.

Objectives

To elucidate the role of LAMs in mediating ibrutinib resistance in MCL.

Methods

We investigated macrophage polarization through multiparameter flow cytometry (MPFC) using antibodies against CD206 and CD86 in blood and tissue samples from patients with MCL, both resistant and sensitive to ibrutinib. Subsequently, we developed an in vitro co-culture model utilizing MCL cell lines to identify cytokines associated with ibrutinib resistance and macrophage M2 polarization. The mechanisms underlying resistance were examined using MPFC, RNA s

SUBMITTER: Sun X 

PROVIDER: S-EPMC12225943 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature