Formononetin derivatives containing benzyl piperidine: A brand new, highly efficient inhibitor targeting Xanthomonas spp.

ABSTRACT:

Introduction

Plant bacterial diseases take an incalculable toll on global food security. The indiscriminate use of chemical synthetic pesticide not only facilitates pathogen resistance of pathogenic bacteria, but also poses a major threat to human health and environmental protection. Therefore, it is of great economic value and scientific significance to develop a new antibacterial drug with environmental friendliness and unique mechanism of action.

Objectives

To design and synthesize formononetin derivatives based on natural products, evaluate their in vitro and in vivo antibacterial activities and elucidate the mechanisms involved.

Methods

The synthesis was carried out by classical active group splicing method. The antibacterial activities were evaluated using turbi

SUBMITTER: Zhang M 

PROVIDER: S-EPMC12225949 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature