Subclinical Myocardial Injury and Global Cognitive Performance: MESA (Multi-Ethnic Study of Atherosclerosis).

ABSTRACT:

Background

Cognitive impairment is common in cardiovascular disease (CVD) patients.

Objectives

The purpose of this study was to evaluate the relationship of myocardial injury, measured by high-sensitivity cardiac troponin T (hs-cTnT), with global cognitive performance and its decline over time.

Methods

Hs-cTnT assessed at baseline (2000-2002) and exam 5 (2010-2012) in 4,445 participants. Cognitive function evaluated using the Cognitive Abilities Screening Instrument (CASI) at exams 5 and 6 (2016-2018). Subclinical myocardial injury defined as hs-cTnT above limits of detection but below 19 ng/L, while clinical myocardial injury >19 ng/L. Cognitive decline was a >5 point decrease in CASI scores from exam 5 to 6. Regression analysis assessed the association of hs-cTnT le

SUBMITTER: Tomar S 

PROVIDER: S-EPMC12226125 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature