Semen HPV and IVF: insights from infection prevalence to embryologic outcomes.

ABSTRACT:

Purpose

Human papillomavirus (HPV), the most common sexually transmitted infection, has been proposed as a potential factor in male infertility. This study aimed to assess the prevalence of HPV in semen samples from men undergoing in vitro fertilization (IVF) in Sweden and evaluate its association with semen parameters and embryological outcomes.

Methods

This prospective cohort study was conducted at Sahlgrenska University Hospital, Gothenburg, Sweden, between January 2023 and February 2024. Men (n = 246) undergoing IVF provided fresh semen samples for HPV DNA testing using real-time PCR. Semen analysis followed WHO guidelines, and fertilization and embryo quality assessments were conducted according to the Istanbul Consensus. Machine learning (ML) models were employed to pr

SUBMITTER: Francis J 

PROVIDER: S-EPMC12226446 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature